Daniel L. Rolnik et al. Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia New England Journal of Medicne 28th June 2017
Preterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia.
This multicenter, double-blind, placebo-controlled trial, randomly assigned 1776 women with singleton pregnancies who were at high risk for preterm preeclampsia to receive aspirin, at a dose of 150 mg per day, or placebo from 11 to 14 weeks of gestation until 36 weeks of gestation. The primary outcome was delivery with preeclampsia before 37 weeks of gestation.
Treatment with low-dose aspirin in women at high risk for preterm preeclampsia resulted in a significantly lower incidence of preterm preeclampsia than that with placebo.
Full article available via the New England Journal of Medicine