A survey of the dose of inhalational agents used to maintain anaesthesia in infants

Brinkman, E.N. et al. European Journal of Anaesthesiology. Published online: November 10 2016

B0005908 Development of brain power
Image source: Bill McConkey – Wellcome Images // CC BY-NC-ND 4.0

Background: Various animal studies suggest that currently used anaesthetics are toxic to the developing brain. Many reviews advise that the total anaesthetic drug exposure should be reduced but the dose usually used in clinical practice has not been clearly elucidated.

Conclusion: The concentration of inhalational anaesthetics in %MAC increased with age and was lowest in neonates. Most young infants received inhalational anaesthetics at a concentration below 1 MAC, which accords with current guidance to minimise anaesthetic drug exposure but may have unintended consequences.

Read the abstract here


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